While lower-depend MBL seldom progresses to CLL, large-count MBL progresses to CLL requiring therapy at a charge of one% to two% each year. Superior-rely MBL is distinguished from Rai 0 CLL determined by if the B-cell depend is previously mentioned or down below five × 109/L. Though folks with the two substantial-count MBL and CLL Rai stage 0 are